What autoimmune diseases cause hyperpigmentation?
Lupus erythematosus (LE) is an autoimmune disorder commonly affecting the skin; cutaneous lesions may indicate systemic involvement, warranting further evaluation. Photosensitivity, which may result in hyperpigmentation, is a well-known feature of the disease.
What autoimmune diseases affect the skin?
There are several common autoimmune diseases that affect the skin. These include vitiligo, scleroderma, lupus, psoriasis and vasculitis.
What disease can cause skin discoloration?
Vitiligo is a condition in which the skin loses its pigment cells (melanocytes). This can result in discolored patches in different areas of the body, including the skin, hair and mucous membranes. Vitiligo (vit-ih-LIE-go) is a disease that causes loss of skin color in patches.
What autoimmune disease causes blotchy skin?
Lupus Can Cause a Rash Across the Nose and Cheeks
A butterfly-shaped rash across your nose and cheeks is the classic hallmark of lupus, an autoimmune disease that starts when your body attacks your organs and tissues and leads to inflammation. You may also experience lesions on your skin after sun exposure.
What deficiencies cause hyperpigmentation?
The hyperpigmentation related to vitamin B12 deficiency is more common in darker-skinned patients. Few other cases of skin hyperpigmentation due to vitamin B12 deficiency have been reported in the literature. The mechanism of hyperpigmentation is due to increased melanin synthesis rather than a defect in melanin.
What does hyperpigmentation look like in Addison’s disease?
When stimulated, the melanocyte changes the color of pigment to a dark brown or black. Hyperpigmentation is usually generalized but most often prominent on the sun-exposed areas of the skin, extensor surfaces, knuckles, elbows, knees, and scars formed after the onset of disease.
What does autoimmune rash look like?
Autoimmune rashes can look like scaly red patches, purplish bumps, or more. The appearance of autoimmune rashes will be different, depending on which autoimmune condition is triggering the skin rash. For example, cutaneous lupus may cause a scaly red patch that does not hurt or itch.
What does Sjogren’s rash look like?
Sjogren’s syndrome patients often develop a purple-to-red rash that does not lighten when pressure is applied. They may also show purpura (rashes with blood spots) that’s indicative of vasculitis (inflammation of blood vessels). If you observe any of these rashes on your skin, consult a dermatologist.
What diseases are considered autoimmune?
Common autoimmune disorders include:
- Addison disease.
- Celiac disease – sprue (gluten-sensitive enteropathy)
- Graves disease.
- Hashimoto thyroiditis.
- Multiple sclerosis.
- Myasthenia gravis.
- Pernicious anemia.
What hormone causes skin discoloration?
“The underlying hormone responsible for triggering the melanocytes is melanocyte stimulating hormone (MSH). This hormone increases the production of melanin, which is responsible for darkening the skin.”